The objectives of this study is to investigate the effect of toloxatone and ethanol on monoamine oxidase (MAO) activity in rat’s brain, liver and intestine using tyramine and benzylamine as the substrate. The results were as follows : There was significant differences(p<0.05) in MAO activity of brain, liver and intestine compared to control in toloxatone administered group with tyramine and benzylamine as the substrate. But M AO activity was significantly inhibited in higher toloxatone concentration as using benzylamine as the substrate rather than using the tyramine as substrate. There was significant differences(p<0.05) in MAO activity compared to control only in the concentration of 5 X 10_1 M and 1 M in ethanol administered group. Specifically, in comparative analysis of E C 50, MAO activities were more significantly inhibited in the tyramine using group than the benzylamine using group in toloxatone administered group, and MAO activity was significantly inhibited in lower toloxatone concentration at intestine rather than brain and liver. But ethanol administered group was not significantly inhibited. These results suggest that toloxatone has more specific affinity to MAOa but not in the case of ethanol.
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