Object : This study was designed to evaluate the abnormal neurologic signs of female schizophrenic and mood disorder patients. Method : Hospitalized female DSM-III-R diagnosed schizophrenic and mood disorder patients under age of 35 years, 20 patients in each group, and 20 normal control underwent neurologic examination using Merriam’s neurologic signs inventory which assessed prefrontal, parietal, praxis, fine motor coordination and non-localizing signs. The scores of neurologic signs were converted into Z-scores, and compared between three groups by oneway ANOVA, and the correlation between neurologic signs and clinical characteristics were tested in schizophrenic group. Results : Schizophrenic group had significantly higher abnormal neurologic signs than either normal control group or mood disorder group. Mood disorder group had significantly higher abnormal neurological signs than normal control group. In schizophrenic group prefrontal sign had significant correlation with duration of illness(r= 0.92, P<C0.001) and previous numbers of hospitalization(r= 0.79, P〈0.001). Conclusions • Female schizophrenic patients had more abnormal neurological signs than normal control and mood disorder group. The correlation between the abnormal neurological signs and duration of illness suggests that the abnormal neurological signs could be a predictor of chronicity in schizophrenia.
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