Objective : To test the hypothesis that structural change of brain contributes as a biological marker to classify the subtype of schizophrenia by evaluating whether dopaminergic activities are different between normal ventricle group and large ventricle group, and also to confirm that response of serum prolactin to neuroleptics may predict clinical response of symptom in a specific subgroup o f schizophrenia. Methods : Serum prolactin level and psychopathology were measured before neuroleptic administration and at 72hrs, 2wks, and 4wks after medication in 21 chronic male schizophrenicsC 14 normal ventricle group, 7 large ventricle group). Results : The changes of serum prolactin level during the total course of treatment were significant in both groups, but pattern and degree of interval changes were different between the two groups. The changes of positive symptom during the total course of treatment were significant in both groups, but the correlation between serum prolactin level and positive symptom was significant only in normal ventricle group, and change of negative symptom during the total course of treatment were also significant only in normal ventricle group. In normal ventricle group, the early 72hr response of Serum prolactin level to neuroleptics was significantly correlated with overall change of positive symptom Conclusion : Above results suggest that functional abnormalities of dopaminergic pathway rather than changes in amounts of dopaminergic activites are more important in such a subtyping and formation of psychopathology. And these findings lead further support to the hypothesis that structural change of brian may be a meaningful biological marker in subtyping schizophrenia. And in normal ventricular group, the early 72hr response of serum prolactin level to neuroleptics might predict clinical response of positive symptom.
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