This study was conducted to analyse effects of lithium on human cellular immune function, with 8 patients (male : 5 persons, female * 3 persons and average age * 33) who were taken to the Department of Psychiatry, Kyungpook National University Hospital while beling suitable for the bipolar disorder’s criteria of DSM-HI-R and RDC. Then, no medicine was administrated to these 8 patients prior two months to administration of lithium. This study was carried out by testing and comparing the function of human immune function (test of lymphocyte( % ), monocyte(%), granulocyte(% ), cell( % ) count by Flow cytometer), before administrating lithium and at 60 days after its administration. The result of human immune function indicated that there are statistically remarkable increase in T lymphocyte and helper cells and decrease in natural-killer cell (P〈.05), while there is no statistically any significant change in lymphochte, monocyte, granulocyte, B lymphocyte, suppressor cells and T4/ T8 ratio.
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