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This study was designed to investigate antipsychotic properties of cholecystokinin-octapeptide (CCK-8) in schizophrenic patients. Subjects were 30 chronic schizophrenics with residual symptoms following stablization with antipsychotic drugs. CCK-8 (0.2jig/kg) or placebo was administered intravenously single injection with double-blind method while patients received constant dose of antipsychotic drugs. The clinical effect of CCK-8 was evaluated with BPRS which was applied to patients 2 hours before and 3 and 7 days after drug administration. Results showed no significant differences between CCK-8 group and placebo group.
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