Zipeprol, an antitussive agent, abuse has recently increased among adolescents. The authors experienced 6 cases of zipeprol abuse complicated with convulsion and cerebral perfusion defects. They all had experienced drowsy consiciousness, euphoria, and hallucination during the intoxication of zipeprol. One of them had experienced aggressive impulses rather than euphoria. Another one had experienced fear due to persecutory delusion. They habitually used the drug in doses 1.5—7 times higher than the recommended dose. They all, who had never had seizure history, had generalized tonic-clonic seizures during the period of intoxication. The withdrawal symptoms, which were sleep difficulty, headache and anxiety, appeared 1- 4 days after discontinuation of the drug and persisted for 3—4 days. The single photon emission tomography of the brain showed multiple defects of perfusion in the temporal, occipital cortex and basal ganglia.
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