The effect of caffeine on the negative symptoms of schizophrenia was studied. Twenty three schizophrenics of the negative type were treated with caffeine and placebo in a double blind cross-over design. For a period of 5 weeks, the symptoms were evaluated using Positive and Negative Syndrome Scale, Scale for the Assessment of Negative Symptoms and Negative Symptom Rating Scale. The results were as follows : 1) The negative symptoms improved significantly after one day of caffeine administration in all three scales of the measurement and this effect continued up to 7days of caffeine administration in two scales out of three. This effect however disappeared after 2 weeks of caffeine treatment in all three scales. 2) No significant effect was observed in positive scores and general psychopathology scores of Positive and Negative Syndrome. The above results suggest that caffeine has only transient therapeutic effect on negative symptoms of schizophrenia.
서 론
연구대상 및 방법
결 과
고 찰
결 론
참 고 문 헌