The effect of chronic administration of fluoxetine on blood alcohol concentration and on a number of alcohol induced physical and psychological effects was studied. The subjects were 14 hospitalized alcoholics without significant depression. After 21 days of 60mg daily fluoxetine and placebo administration, 2.5ml/kg body weight of 40% alcohol was administrated in a single dose and blood alcohol concentrations were measured 10，20，40, 60, 120，and 240min. after the alcohol intake. Mania Rating Scale score (MRS), pulse rate, respiratory rate and subjective physical condition were measured before and 30min. after alcohol intake. The results were as follows : 1) Blood alcohol concentrations were significantly higher after fluoxetine administration than placebo administration at 40min. and 60min. after alcohol intake. 2) Fluoxetine suppressed the increase of pluse rate induced by alcohol intake. However, no significant difference was noted in the alcohol induced changes in the scores of MRS, respiratory rate, and subjective physical condition between the drug and placebo administrations. 3) After fluoxetine administration, a significant negative correlation was shown between blood alcohol concentration, lOmin after alcohol intake and MRS. In contrast, however, a significant positive correlation was seen between the two variables after placebo administration. From these results, it is suggested that fluoxetine increases blood alcohol concentration only during higher alcohol concentration and that the reduction of alcohol intake after chronic administration of fluoxetine may be due, at least in part, to an attenuation of positie reinforcement of alcohol effect, rather than to an enhancement of the aversion reaction to alcohol
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