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KCI등재 학술저널

가족력 유무에 따른 정신분열병 환자의 뇌척수액 MHPG, HVA 및 5-HIAA 농도에 관한 연구

A Study of Cerebrospinal Fluid MHPG, HVA and 5-HIAA Concentrations in Schizophrenic Patients with and without Family History

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Objects : This study was designed to investigate the validity of subtyping schizophrenia by family histoiy and to find out the biochemical markers reflecting the etiological heterogeneity between the subtypes. Methods : Cerebrospinal fluid (CSF) concentrations of MHPG , HVA, and 5—HIA A were determined in 19 schizophrenic patients with family history and 13 patients without family history. And their psychopathology were also assessed with PANSS. Results : In schizophrenic patients with family history of schizophrenia, CSF MHPG concentrations were significantly lower than those in patients without family history. And there were significantly higher concentraions of CSF HVA in schizophrenic patients with family history compared with those in patients wihtout family history. Among general psychopathology subscales somatic concem (Gl) and uncooperativeness(G8) subscales were higher in patients with family history. Conclusions : These results suggest that central noradrenergic activity may be decreased and/or the central dopaminergic activity increased in schizophrenics with family history compared to those without family history. Although not sure to indicate that CSF MHPG and HVA levels are biological markers of genetic etiology, these findings support the family history positive and negative dichotomy of schizophrenia

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