양성 및 음성증상 정신분열병환자에서 Sulpiride 투여후의 임상적 호전도와 혈중 약물농도와의 관계

The Clinical Effects and Serum Concentrations of Sulpiride in Positive and Negative Symptom Schizophrenics

It has been suggested that positive and negative symptom schizophrenia have different pathophysiology and cause. The authors administered fixed dosage of sulpiride, an atypical antipsychotics, to schizophrenic patients (DSM-III-R) as scheduled for the duration of 6 weeks. Every 2 weeks the psychotic symptoms were rated with Positive and Negative Syndrome Scale (PANSS). The serum neuroleptic levels measured by NRRA were correlated with oral dosage(R2=0. 36336)，but not with clinical improvement