The purpose of this study was to examine the effects of tricyclics on urinary M H PG level and plasma cortisol level and to investigate the interaction of noradrenergic system with HPA axis in major depression. The subjects were 24 inpatients with major depression diagnosed according to DSM-III-R. Seventeen medical students and residents served as a control group. 24-hour uinary M H PG and plasma cortisol concentration at 08 : 00 a.m were measured at various points during treatment The results were as follows: 1) No significant difference was found between the urinary MH PG excretion for either depressed patients or comparison subjects. 2) The pretreatment urinary M H PG level and therapeutic response to tricyclic antidepressants did not correlate. 3) Significant positive correlation was found between pretreatment 8 : 00 a.m. plasma cortisol levels and urinary M H PG levels in depressed patients(r=0.54, p<0.05). After tricyclics medication, negative correlation was observed, but was not significant(r= — 0.41，p=N S).
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