주정 의존의 정도와 생화학적 임상병리 검사의 이상 소견과의 관련성

Relationship of the Severity Alcohol Dependence and the Abnormality of Biochemical Laboratory Tests

To assess the predictability of abnormality in biochemical laboratory tests in patients with alcohol dependence the authors investigated 97 patients (43 alcohol dependence patients and 54 control patients) who received admission care in Hangang Sacred Heart Hospital from March 1，1991 to July 31，1991. The patients with alcohol dependence were classified into mild (N = 7 ), moderate(N=22) and severe(N= 14) according to the DSM-III-R criteria for severity. Control patients were 28 psychiatric patients and 26 ENT or ophthalmologic patients who did not meet the diagnostic criteria o f alcohol dependence. The results were as follow : 1) When the effect of age is controlled, the possibility o f the abnormality of SGOT, SGPT and gamma-GTP increases 2.743, 2.073 and 1.829 times respectively for each step increment of the alcohol dependence severity. 2) SGPT’s abnormality was influenced by SGOT or gamma-GTP’s abnormality, and gamma- GTP’s abnormality was influenced by SGOT or SGPTs abnormality. But the possibility of abnormality of SGOT increases 2.399 times(95% C.I. ; 1.277-4.507) for each step increment of the alcohol dependence severity even after the effect of age, SGPT and gamma-GTP were controlled. 3) When the effect of age is controlled, there is no significant relationship between the abnormality of Albumin, Creatinine, Alkaline phosphatase, Uric acid or Triglyceride and the severity of alcohol dependence. From the results, we found the importance of rating severity of alcohol dependence, which can predict the abnormality of biochemical laboratory tests such as SGOT，SGPT and gamma- GTP. We recommend the rating of severity in each patient with alcohol dependence for better understanding and management of patients’ psychiatric and physical condition