“Lithium Ion 이 內分泌系臟器에 미치는 影響에 關한 實驗的 研究

The Effects of Lithium Ion on Endocrine Organs

The experimental work was done on white male rats, weighing between 170gm and 220gm. The experimental group was divided into A,B,C subgroup. In A and B subgroup Licl solution in a dose of 2 mEq. per Kg was injected intraperitoneally for 4 days and 7 days respectively. In C subgroup Licl in a dose of 1 mEq. per Kg was injected intraperitoneally for 12 days. The control group was injected with normal saline intraperitoneally. In both experimental and control group 100juc of P32 and 7juc of I131 were res pectively injected on 4th, 7th and 12th day intraperitoneally to a group of rats. The animals were sacrified 10 hour after the last injection. The following results were obtained. 1. The weight of endocrine organ and radioactive tracer uptake after lithium administration were found reduced in thymus, testicles and seminal vesicles, whereas in adrenals these were found increased. In thyroid I131 uptake was decreased, although P32 uptake was remarkablley increased. 2. After lithium administration thyroid showed enlarged follicles, in which profuse thin colloidal substance was observed. Adrenals showed hypertrophic zona fasdculata, while the medulla was notablly atrophic. Subsquent hyperfunction of thyroid and adrenal cortex were observed. 3. Thymus and seminal vesicles [showed remarkable atrophy and subsquent hnpofunction of them were noted.