Chlorpromazine 의 副作用과 Sustained Trihexiphenidyl Hcl(Antane)에 依한 雜體外路系 反應의 調節

SIDE EFFECTS OF CHLORPROMAZINE AND THEIR MANA-GEMENT WITH SUSTAINED TRIHEXYPHENIDYL Hcl(ARTANE) FOR DRUG INDUCED EXTRAPYRAMIDAL REACTIONS

The authors tried to study on the side effects of Chlorpromazine, evaluate the effect of Artane (Trihexyphenidyl Hcl) and observe the recurrence rate of extrapyramidal reaction after the withdrawal of maintenance doses of Artane. This study includes 28 patients who were hospitalized in Psychiatric ward SNUH and 55 patients in Kaejoug Mental Hospital, Cholla Pukdo Province. (Total; 83 patients) The results are as follows. 1. Most of patients showed musuclar weakness and drowsiness, though they were rarely volunteered symptoms. Dizziness and dryness of mouth were observed in more than an half of cases. Nasal stuffness and extrapyramidal reactions were developed among 49% of cases. 2. Extrapyramidal symytoms were appeared one days later the initial administration of chlorpromazine. The authors could observe that torticollis was relatively early appeared symptom and tremor tended to be appeared later. 3. The authors were impressed that the amount of chlorpromazine did not determined the appearance of extrapyramidal symptoms. 4. Artane was administered to 44 cases. But 3 casesof neurologic illness, 5 cases, from whom significant data were not obtainable because of discharge within 10 days without being managed, and 4 cases, for whom Artane was supplied’ irregularly, were excluded from this study. 5. 85% of extrapyramidal symptoms were managed successfully with Artane. To manage them, successive 4 days of Artane administration (5-lOmg daily) were needed. 6. Artane was more effective in rigidity than in tremor and especially highly effective in the management of torticollis and oculogyric crises. 7. The side effects of Artane were not significant. 8. Extrapyramidal symptoms were reappeared in 11 cases amang 15 cases within 20 days after the withdrawal of daily maintenance doses of Artane (5-lOmg). 9. Among three neurological cases, two cases revealed the much improvement.