Meprobamate Chlorpromazine 및 電擊療法이 白鼠의 Estrous Cycle에 미치는 影響

EFFECT OF MEPROBAMATE , CHLORPROMAZINE AND EST ON THE ESTROUS CYCLES IN THE ALBINO RAT

The cyclical activity of the Sprague-Dawley strain rat was observed under the various conditions of administration of meprobamate, chlorpromazine and EST, using the vaginal smear technique. The experimental groups were as followings； Group I Normal control rats Group Et Rats administered with meprobamate in doses of 60mg/kg/day Group m Rats administered with meprobamate in doses of 400 mg/kg/day GroupIV Rats administered with meprobamate in doses of 400mg/kg/day and chlor-promazine, 20mg/kg/day Group V Rats administered with meprobamate in doses of 60mg/kg/day and chlorpromazine, 20mg/kg/day GroupVI Rats administered with meprobamate in doses of 60mg/kg/day and chlorpromzine, 5 mg/kg/day GroupVD Rats administered with meprobamate in doses of 60-400mg/kg/day combined with EST. In Group II and III，the average length of the estrous cycle was 9.64 and 10.02 days, which revealed the significant prolongation in comparison with 4. 9 days in the normals. Group IV and V showed complete cessation of estrous state of the cycle. Group VI had irregular cyclical activity, showing 14.4 days interval of the cycle. Group V II had complete cessation of estrous stage of the cycle immediately after EST. It seems significant that meprobamate has an effect on the cyclical activity of the estrous cycle, which is increased if combined with chlorpromazine or EST.