Phenothiazine系 藥物에 依한 spasmodic torticollis

It has been recognized that so-called “more potent phenathiazine derivativer，, on a miliigram for milligram basis can produce acute dyskinetic syndromes of various kinds this is particularly so with phenothiazines of piperazine side chain group such as perphenazine, thiopropazate and prochlorperazine etc. In contrast, phenothiazines of aminopropyl side chain group are supposed to cause such manifestations very rarely The authors have observed spasmodic torticollis in adolescent boys who had been on relatively low dose of chlorpromazine. Torticollis could be controlled either by caffein soduim benzoate or by sod. amgtal without discontinuance of chlorpromazine So far we have not encountered similar manifestation in calorpromazine-treated adults.