노인인구에서 ApoE 유전자형에 따른 머리둘레와 인지기능간의 연관성

Correlation between Head Circumference and Cognition in the Elderly by ApoE Genotype

Objectives：The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community. Methods：A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype. Results：On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE ε4 allele, current smoking and alcohol drinking status (β=0.15, p=0.04). Only in the lowest quartile group, presence of ApoE ε4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alcohol drinking and smoking status (β=-1.39, p=0.008). Conclusion：These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE ε4 allele may be a medicating factor