Objectives:The relationship between substance dependence and poor decision making has received much attention in recent years. This study aimed to test the hypothesis that alcohol dependent subjects would demonstrate a more perseverative decision-making pattern, during ambiguous situations. Methods:15 alcohol dependent patients and 15 healthy normal controls performed a novel computerized decision-making task, which presented figures of coins. The subjects were instructed to guess whether the total number of coins was ‘odd’ or ‘even’. Besides these two response, one could select a third alternative – ‘pass’ – in case the chances were assumed to be low. Results:There was significant difference in performance between the two groups (F=4.339, p=0.008). The control group gained 15.4±14.4 points, whereas the alcohol dependent group lost 0.6±5.3 points. The normal control group demonstrated a tendency to make more pass responses as the trials were repeated. In contrast, the alcohol dependent group didn t make use of the alternative, but kept challenging between ‘odd’ and ‘even’, although they sensed that the chances were low. Conclusion:The alcohol dependent patients demonstrated a more rigid and perseverative response pattern and showed deficits in making use of compromise alternatives
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