혈액투석을 받는 만성신부전 환자에서 야간수면의 특성과 삶의 질과의 연관성

The Association of Nocturnal Sleep Pattern with the Quality of Life in Chronic Renal Failure Patients on Hemodialysis

Objectives：We aimed to compare the quality of life (QOL) between patients with chronic renal failure (CRF) and normal control subjects, and to examine the relationship of QOL with the sleep characteristics in CRF patients. Methods：The Epworth Sleepiness Scale (ESS) and World Health Organization Quality of Life assessment instrument-Brief form (WHOQOL-BREF) were administered to 26 CRF patients (male：20 Age：53.5±8.7 years) and 26 age- and sex-matched control subjects (male：20 Age：51.9±9.7 years). Nocturnal polysomnography (Embla S7000 Medcare system, New York, USA) was conducted for 26 CRF patients to measure the sleep parameters. Results：The total score and all the subscale scores of WHOQOL-BREF in the CRF patients were lower than those of the control subjects (p<0.01). The amount of rapid eye movement sleep (REMS) was positively correlated with the physical health domain score (r=0.457). In addition, there were significantly negative correlations of the respiratory disturbance index and hypopnea index with the physical health domain score (r=-0.415, -0.616). Conclusion：The QOL of CRF patients was lower than that of the normal controls. Particularly, lower QOL of the physical health domain in CRF patients was associated with greater severity of sleep breathing disorder and lower amount of REMS