정신분열병 환자에서 통계적 확률 해부학 지도를 이용한 확산텐서영상 연구： 겉보기 확산 계수 지도를 이용한 고찰ㅍ

Diffusion Tensor Imaging in Schizophrenia with Statistical Probabilistic Anatomical Mapping：A Study of the Apparent Diffusion Coefficient Map

Objectives：Diffusion tensor imaging (DTI) studies of schizophrenia, thus far, have mainly focused on white matter abnormalities reflected in anisotropy indices such as fractional anisotropy (FA), but recently, new implications of apparent diffusion coefficient (ADC) have been proposed. This is, to our knowledge, the first study to analyze ADC maps of schizophrenic patients using statistical parametric anatomical mapping (SPAM). Methods：DTI was performed in 20 schizophrenic patients and an equal number of age- and sex-matched healthy controls. ADC maps were then generated, from which 98 volumes of interest were extracted using SPAM. Probability-weighted mean values of ADC were calculated from each volume of interest and compared between the two groups. Results：Significantly higher mean ADC values were observed in patients with schizophrenia compared to healthy controls in the following volumes of interest: bilateral hippocampal formation, bilateral uncus, right thalamus, right temporal lobe white matter, right superior temporal gyrus, bilateral insula and right lateral ventricle. Conclusion：The results support the recently proposed assertion that regionally increased ADC may reflect cortical brain atrophy. In addition, a new possibility is raised that a neuropathological event involving both the gray and the white matter may also play a role.