Objectives：The purpose of this study was to examine the determinants of care burden of caregivers in patients with dementia. Methods：128 dementia patients and patients’ caregivers participated in this study. Care burden using the BI；cognition using the K-MMSE；dementia severity using the CDR；activities of daily living using the S-ADL and the S-IADL；behaviour problems using NPI were measured. Results：The results showed that care burden was related significantly with the K-MMSE, the CDR, the S-ADL, the SIADL and the NPI total score. Of the behavior problems, agitation/aggression, anxiety, disinhibition, irritability, and aberrant behavior correlated positively with care burden of caregivers. Regression analysis indicated that agitation/aggression, anxiety, the CDR contributed to care burden. Conclusion：Agitation/aggression, anxiety and dementia severity contributed to care burden of caregivers. The identified determinants of care burden and the stress of caregivers suggest areas of therapeutic intervention to reduce caregiver’s burden so that the institutionalization can be delayed.
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