정신분열병 환자에서 세가지 청각 자극“Oddball” 모형에 의한 사건관련전위 P3a와 P3b

Event-Related Potential P3a and P3b using 3-Stimulus Auditory “Oddball” Paradigm in the Patients with Schizophrenia

Objectives：Using 3-stimulus auditory “oddball” paradigm reflecting fronto/central and temporo/parietal functions simultaneously, we examined patients with schizophrenia. Methods：Fifteen patients with schizophrenia from outpatient clinic and fifteen normal controls from hospital staffs were recruited for the study. To elicit P3a and P3b, 3-stimulus auditory oddball paradigm was employed. The 3-stimulus auditory oddball paradigm was composed of standard tone (1,000 Hz, 75 dB, 80%), target tone (2,000 Hz, 75 dB, 10%) and distracte (White noise, 95 dB, 10%). Results：P3a and P3b were prominent in fronto/central and temporo/parietal areas, respectively, in both schizophrenics and normal controls. The P300 amplitude in patients with schizophrenia was reduced across P3a and P3b (p<0.01). The P300 latency in patients with schizophrenia was delayed across P3a and P3b (p<0.01). Conclusion：These results were consistent with frontal and temporo-parietal lobe dysfunctions in schizophrenics. The 3- stimulus auditory paradigm could be applied for patients with schizophrenia and useful for further exploration the disorder