Alcohol use disorders and related problems continue to constitute a significant public health problem, leading to many psychiatric conditions, physical illnesses, and social problems such as domestic violence and occupational disabilities. Here, we provide an update on alcohol use disorders；1) genetic and neurobiological aspect, 2) neuroimaging study findings, 3) treatment of medical complications 4) psychotherapeutic approaches 5) pharmacological treatment and 6) women and offsprings issues of alcohol use disorders