과민성 장증후군 환자에서 베타 아드레날린 수용체 기능의 활성도와 불안 수준

Beta-adrenergic Receptor Function and Anxiety in Patients with Irritable Bowel Syndrome

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Objectives：Recently, irritable bowel syndrome (IBS) is known to be related with neurotransmitters. This study was designed to determine β-adrenergic receptor function in patients with IBS and to compared with normal controls to examine the relationship between β-adrenergic receptor function and anxiety in IBS patients. Methods：Eighteen IBS patients were compared with the same number of age and sex-matched normal subjects in terms of β-adrenergic receptor function and psychological variables reflecting anxiety levels. To assess β-adrenergic receptor function, Chronotropic 25 dose (CD25) was calculated via isoproterenol stimulation test. Results：CD25 values in the patient group were significantly lower than those in the control group, which reflected increased β-adrenergic receptor function (2.19±1.08 versus 3.89±1.64, p<0.05). Patients with IBS showed higher HAM-A scores (8.88±4.88 versus 3.59±2.65, p<0.01), HAM-D scores (6.41±4.02 versus 2.47±2.40, p<0.01), BDI scores (9.00±6.21 versus 4.72±4.30, p<0.05), and STAI scores (STAI-S：43.41±6.34 versus 33.83±8.18, p<0.01, STAI-T：44.65±7.43 versus 38.17±8.45, p<0.05). In addition, HAM-A scores were negatively correlated with CD25 values in the patient group (r=-0.424, p<0.01). Conclusion：These results suggest that β-adrenergic receptor function is increased in patients with IBS, which could affect increased anxiety levels in these patients