Objectives:Recently, irritable bowel syndrome (IBS) is known to be related with neurotransmitters. This study was designed to determine β-adrenergic receptor function in patients with IBS and to compared with normal controls to examine the relationship between β-adrenergic receptor function and anxiety in IBS patients. Methods:Eighteen IBS patients were compared with the same number of age and sex-matched normal subjects in terms of β-adrenergic receptor function and psychological variables reflecting anxiety levels. To assess β-adrenergic receptor function, Chronotropic 25 dose (CD25) was calculated via isoproterenol stimulation test. Results:CD25 values in the patient group were significantly lower than those in the control group, which reflected increased β-adrenergic receptor function (2.19±1.08 versus 3.89±1.64, p<0.05). Patients with IBS showed higher HAM-A scores (8.88±4.88 versus 3.59±2.65, p<0.01), HAM-D scores (6.41±4.02 versus 2.47±2.40, p<0.01), BDI scores (9.00±6.21 versus 4.72±4.30, p<0.05), and STAI scores (STAI-S:43.41±6.34 versus 33.83±8.18, p<0.01, STAI-T:44.65±7.43 versus 38.17±8.45, p<0.05). In addition, HAM-A scores were negatively correlated with CD25 values in the patient group (r=-0.424, p<0.01). Conclusion:These results suggest that β-adrenergic receptor function is increased in patients with IBS, which could affect increased anxiety levels in these patients
서 론
방 법
결 과
고 찰
결 론
REFERENCES