Objectives:The role of cytokines has been one of the focal points of etiologic research in major psychiatric disorders. This study was designed to analyze the polymorphism of TNF-α and to investigate its relationship with schizophrenia and bipolar disorder. Methods:241 schizophrenic patients and 89 bipolar patients diagnosed by DSM-IV criteria were included as patient groups and 125 normal poplulation from the Catholic Hemopoietic Stem Cell Information Bank (Seoul, Korea) were used as a control group. DNA was extracted from the whole blood, amplified by polymerase chain reaction, and digested by NcoI. Then the obtained RFLP of two alleles, TNFA*1 with 87 bp and 20 bp, and TNFA*2 with 107 bp were assessed. All data were analyzed by χ2 test. Results:The genotype and allele distributions in patients with bipolar disorder were significantly different from those in the controls. There were no significant differences in genotype frequencies of TNFA*1/1, TNFA*1/2, and allelic frequencies of TNFA*1 and TNFA*2 between the schizophrenic patients and the controls. Conclusion:In the present study we observed a significant association between the TNFA*2 allele with bipolar disorder, with negative result on the association of the polymorphism of TNF-α gene with schizophrenia. Consecutive further studies including diverse clinical variables would be required.
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