-G308A Tumor Necrosis Factor-α 유전자 다형성과 주요 우울장애의 연합연구

Possible Association between -G308A Tumor Necrosis Factor-α Gene Polymorphism and Major Depressive Disorder

Objectives：The present study was to examine possible association between the -G308A tumor necrosis factor (TNF)-α gene polymorphism and major depressive disorder (MDD) in Korean. Methods：108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Results：Genotype and allele distributions in patients with MDD (p=0.02, p=0.01, respectively), were significantly different from those of the controls. Conclusion：The present study suggests that the -G308A TNF-α gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.