Paroxetine과 Carvedilol의 약물 상호작용으로 유발된 서맥

A Provoked Bradycardia Associated with a Combination Treatment of Paroxetine and Carvedilol

Selective serotonin reuptake inhibitors (SSRIs) have been used for patients with depressive disorder because of their favorable side effect profiles. However, SSRIs have variable drug interactions because of the inhibitory action on the Cytoch-rome-P 450 system (CYP450), especially in combination with antipsychotic and antiarrhythmic drugs. We hereupon present the first case report of bradycardia associated with the use of paroxetine and carvedilol combination in a patient with depressive disorder