한국인 정신분열병 환자의 HLA-DQA1, HLA-DQB1, HLA-DRB1 대립유전자 빈도

HLA-DQA1, HLA-DQB1, and HLA-DRB1 Allele Frequency in Korean Patients with Schizophrenia

연구목적： 저자들은 PCR-SSOP 방법으로 한국인 정신분열병 환자에서 HLA-DQA1, HLA-DQB1 및 HLA-DRB1 과 정신분열병의 감수성과의 상관성을 밝히고자 하였다. 방 법： DSM-Ⅳ에 의거하여 정신분열병으로 진단된 환자군 128명과 정상대조군 160명에 대해 polymerase chain reaction-sequence specific oligonucleotide probes(PCR-SSOP) 방법을 이용하여 HLA-DQA1, HLADQB1, HLA-DRB1 대립유전자의 빈도를 분석하였다. 결 과： HLA-DQB1*04는 환자군에서 14.6%로 정상대조군의 8.2%보다 높은 빈도를 보였고(p＝0.028), HLADRB1* 14는 환자군에서 11.8%로 정상대조군의 5.5%보다 높았으며(p＝0.01), HLA-DRB*15는 환자군에 서 2.0%로 정상대조군의 7.1%보다 낮은 빈도를 보였고(p＝0.007), HLA-DRB*16은 환자군에서 1.6%로 정상대조군의 4.8%에 비해 유의하게 낮았다(p＝0.043). 결 론： 한국인 정신분열병 환자에서 HLA-DQB1*04와 HLA-DRB1*14는 질병 발생의 감수성 인자로 작용을 하고, HLA-DRB1*15와 HLA-DRB1*16은 방어적인 역할을 할 수 있다고 할 수 있으나, 다른 인종에 관 한 외국의 연구자들의 결과와는 상이한 양상을 보였다

Objective：The aim of this study was to investigate the correlation between HLA-DQA1, HLADQB1 and HLA-DRB1 alleles and disease susceptibility in Korean schizophrenic patients. Methods：HLA-DQA1, HLA-DQB1, and HLA-DRB1 allele typing were performed using polymerase chain reaction-sequence specific oligonucleotide probes(PCR-SSOP) method in 128 Korean schizophrenic patients diagnosed by DSM-Ⅳ criteria, who were not blood-related, and 160 normal blood bank donors. Results：The HLA-DQB1*04 allele frequency was 14.6% in schizophrenic patients, which was significantly higher than that of normal controls which was 8.2%(p＝0.028). HLA-DRB1*14 allele frequency was 11.8% in patients, which was also more frequent than that of normal controls which was 5.5%(p＝0.01). HLA-DRB*15 allele frequency was 2.0% in patients, which was significantly lower than that of normal controls which was 7.1%(p＝0.007) and HLA-DRB*16 allele frequency was 1.6% in patients, which was also lower than that of normal controls which was 4.8%(p＝0.043). Conclusions：Schizophrenia in Korea had positive correlation with HLA-DQB1*04 and HLADRB1* 14, and negative correlation with HLA-DRB1*15 and HLA-DRB1*16. These findings support the association of the HLA-DQB1 and HLA-DRB1 with schizophrenia in Korean population, which was different from other study results in other different ethnic groups