A Preliminary Analysis of a Polymorphism in DTNBP1 for Schizophrenia: No Support for an Association

We tried to replicate the previously reported positive association between Dystrobrevin bindang protein 1 gene (DTNBP1) and schizophrenia. Our sample included 241 patients with schizophrenia based on DSM-IV and 194 normal controls. The patient and control groups were matched for their gender proportion and all the subjects were ethnically Koreans. We genotyped P1635 A/G polymorphism (rs3213207) of DTNBP1. We could not find association with DTNBP1 and schizophrenia in this Korean sample. Additional analysis for the subgroup of schizophrenia having familial loading of major psychiatric disorders did not show association, either. In summary, DTNBP1 is less likely to be a major susceptibility gene for schizophrenia in this Korean population. Further studies with more Single nudeotide polymorphisms (SNPs) for the whole gene sequence including the promoters will be necessary to understand the genetic contribution of DTNBP1 for the development of schizophrenia in Koreans.