Clozapine 투여후 설사와 혈소판 감소증이 나타난 환자 1례

A Case with Profuse Diarrhea and Thrombocytopenia Following the Administration of Clozapine

The clozapine has been used to the treatment of schizophrenic patients unresponsive to conventional antipsychotics, but to administration of clozapine has been restricted because of its propensity to cause agranulocytosis. So side effects associated with the administration of clozapine have probably not been fully elucidated. The authors describe a case of a male schizophrenic who developed profuse diarrhea, spiking fever and thrombocytopenia associated with the administration of clozapine. Discontinuance of clozapine therapy resulted in improvement of diarrhea and fever followed by normalization of the platelet count. Previous reports of adverse hematologic side effects and gastroenteric reaction induced by clozapine administration are also discussed. We suggest that the physician must keep in mind these side effects and administer clozapine cautiously.