Methylphenidate 투약에 따른 주의력결핍 과잉운동장애 아동의 청각 사건관련전위의 변화

Altered Auditory Event Related Potentials Following Administration of Methylphenidate in Children with Attention Deficit Hyperactivity Disorder

Objects：Event related potential(ERP) has been recently applied to examine the neurophysiological disturbance in attention deficit hyperactivity disorder(ADHD), particularly with regard to N100 & P300 which are known as one of ERP components closely linked with cognitive function. On the basis of these aspects, this study was designed to evaluate electrophysiologic characteristics and its availability for diagnosis and treatment of ADHD children by comparison of ERP between normal controls and ADHD children before and after methylphenidate(MPD) administration. Methods：We examined the topographic auditory ERP and T.O.V.A.(Test of variables of attention), a standardized computerized visual continuous performance test following administration of stimulant drug, MPD 10mg in 13 ADHD children and compared these results with those of 11 normal controls. Results：The results were as follows： 1) Though the difference was not stastically significant(p＝0.0548), N100 latencies seemed to be longer in ADHD children than in normal controls. N100 amplitudes also seemed to be larger in ADHD children than in normal controls(p＝0.0629). 2) The P300 latencies significantly shortened after MPD administration when compared with those before MPD administration in ADHD group(p<0.01). 3) ADHD group performed significantly less well than normal controls in T.O.V.A.(p<0.05). And T.O.V.A. scores significantly improved after MPD administration in ADHD group(p<0.01). 4) The N100 & P300 latencies and the T.O.V.A. scores were significantly correlated before MPD administration in ADHD group(p<0.05). 5) The P300 latencies before MPD administration were significantly correlated with the amplitudes of changes of T.O.V.A. scores after MPD administration(p<0.05). Conclusion：It seemes that prolonged N100 latency of ADHD children can be regarded as a relatively enduring trait marker and that P300 latency may reflect attentional response ability along with therapeutic effect by stimulant.