정신분열증 환자에서 Haloperidol이 혈청 Interleukins 농도에 미치는 영향

The Effect of Haloperidol on Serum Levels of Interleukins in Schizophrenic Patients

Objective：Altered interleukin(IL) regulation has been regarded as an additional proof that schizophrenia has a viral-autoimmunological background. However, it is possible that abnormalities of ILs may represent a neuroleptic artifact rather than a finding intrinsic to the disorder. Therefore, we studied the effect of haloperidol on serum IL level in schizophrenic patients. Methods：We measured serum levels of IL-1β, IL-2, and IL-6 using quantitative sandwich ELISA method at the day 0(before-medication), week 4 and week 8 in 20 male schizophrenic patients. Results：There were no significant differences in serum IL-1β, IL-2, and IL-6 levels between before medication and at either week 4 and week 8 after haloperidol administration. Conclusions：These findings suggest that at least 8 weeks of haloperidol administration does not affect serum IL-1β, IL-2 and IL-6 levels in male schizophrenics