Calcium iAiosiiiate ceramics 제재의 성견 골막하 이식시 조직반응에 관한 연구

A STUDY OF TISSUE REACTIONS TO CALCIUM PHOSPHATE CERAMICS ON SUBPERIOSTEAL IMPLANTS IN DOGS

The purpose of this study was to observe the tissue reaction to four experimental groups of calcium phosphate ceramics, which are porous hydroxy apatite, dense hydroxyapatite, porous tricalcium phosphate and dense tricalcium phosphate implants, and to the control group of surgical grade Vitallium (Howmedica Inc., New York, N .Y .) after 3 days, 1 week, 2 weeks, 4 weeks and 8 weeks from subperiosteal implantation on maxillary buccal mucosa of 5 dogs. The results were obtained as follows: 1. In all experimental and control groups, marked infiltrations o f acute and chronic inflammatory cells were observed after 3 days, and resorption of alveolar bone, covering of connective tissue with marked decrease in inflammatory reaction were observed after 1 week. 2. In control group, the following were obtained; covering of the thick fibrous tissue wall and infiltration o f acute and chronic inflammatory cells as well as resorption of alveolar bone after 2 weeks, and covering o f fibrous tissue wall, infiltration of osteoblasts and resorption of alveolar bone after 4 weeks, but after 8 weeks only the covering of the fibrous tissue wall. 3. After 2 and 4 weeks, covering of thin fibrous tissue wall without any inflammatory reaction were observed from porous hydroxyapatite and dense hydroxyapatite groups, with additional infiltration of macrophage and resorption of alveolar bone from dense hydroxyapatite groups after 4 weeks, and after 8 weeks, infiltration of macrophages and inflammatory cells as well as osteoblasts and osteoclasts were observed in both groups. 4. After 2 weeks no inflammatory reaction from porous tricalcium phosphate group, and in filtration o f macrophage and chronic inflammatory cells from dense tricalcium phosphate group, but after 4 weeks resorption o f alveolar bone with infiltration o f macrophages, and after 8 weeks, infiltration of macrophages and inflammatory cells as well as osteoblasts and osteoclasts were observed in both groups.