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Histamine이 토끼의 결장뉴 수축에 미치는 영향

Effects of Histamine on Contraction of Rabbit Taenia Coli

The effects of histamine on contraction of rabbit taenia coli were studied. The results obtained were as follows: 1) The contractile response to histamine was appeared at the concentration of 10<sup>-7</sup>M and increased in a dose-dependent manner to the concentration of 10<sup>-4</sup>M. 2) The magnitude of the histamine-induced contractile response was declined during short-term exposure in rabbit taenia coli. After 40-min exposure to histamine, the contractile response did not altered. 3) Histamine-induced contraction was not influenced by hexamethonium(10<sup>-4</sup>M), propranolol(10<sup>-4</sup>M) and phenoxybenzamine(10<sup>-6</sup>M). 4) H<sub>1</sub>-receptor blockade such as chlorpheniramine(10<sup>-6</sup>M) and pyrilamine(10<sup>-6</sup>M) completely abolished the response of the taenia coli to exogenous histamine, while H<sub>2</sub>-receptor blockade (cimetidine, 10<sup>-6</sup>M) did not alter. 5) After the treatment of verapamil the histamine-induced contraction was significantly inhibited, but in the treatment of 2 mM La<sup>3+</sup> it was not influenced. 6) In the absence of Ca<sup>2+</sup>, histamine induced contraction in the different manner of acetylcholine. When taenia coli war treated with atropine(10<sup>-6</sup>M) which was completely blocked the contraction by acetylcholine(10<sup>-4</sup>M), histamine-induced contraction was not altered. These results suggest that in the rabbit taenia coli exogenous histamine induced contraction through H<sub>1</sub>-receptor, but not through the mechanism of acetylcholine.

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