인삼이 적혈구막을 통한 Na⁺ 이동에 미치는 영향

Effect of Ginseng Alcohol Extract on Sodium Movements across the Red Cell Membrane

In an attempt to explore the effect of Ginseng on the permeability of the biological membrane to cations we have investigated the effect of Ginseng-alcohol extract on the transport of Na⁺ human red blood cell preprations. The Na⁺ influx was measured in intact red cells using ²²Na as a tracer and the efflux in reseated red cells using ²⁴Na as a tracer. 1. The influx of Na⁺ was not apparently changed by the Ginseng-alcohol extract of 20mg% in the incubation medium. 2. Similarly, 20mg% Ginseng-alcohol extract in the cellular space did not alter the efflux of Na⁺ from the cell. However, 50mg% of Ginseng-alcohol extract in the cell resulted in a significant increase in the Na⁺ efflux and this effect was magnified when the cell was suspended in the medium containing the Ginseng-alcohol extract in a concentration of 20mg %. The results suggest that Ginseng-alcohol extract over 50mg% increase permeability of red blood cell membrane to Na⁺ by altering the membrane integrity.