알츠하이머 치매에서 경두개 자기자극의 임상적 의의

Clinical Implications of Transcranial Magnetic Stimulation in Alzheimer’s Dementia

The objective is this study is to provide a comprehensive understanding of the clinical implication of ranscranial magnetic stimulation (TMS) in Alzheimer’s dementia (AD). We collected studies using TMS in patients with AD and eviewed 41 identified articles. Thirty five articles were about measures of cortical reactivity, plasticity, onnectivity, and six articles were about the enhancement of cognitive function in AD. Reduced short-latency fferent inhibition and resting motor threshold which reflect cholinergic dysfunction and enhanced cortical xcitability respectively are consistent findings of altered cortical reactivity in AD. In addition, cortical lasticity and connectivity have shown impaired results in AD compared with healthy controls. Repetitively elivered TMS can improve several domains of cognitive function impaired in AD. Although the evidence is still preliminary, TMS has a clinical implication as a diagnostic and therapeutic method in AD. Thorough investigation of factors hat can affect the results of TMS and further studies to clarify the results are needed.