분리 위선세포에서 가역성 프로톤 펌프 억제제 YH1238 및 YH1885의 위산분비 억제효과

Inhibitory Effects of Reversible Proton Pump Inhibitors YH 1238 and YH1885 on Acid Secretion in Isolated Gastric Cells

<P> Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of [<SUP>14</SUP>C]-aminopyrine and [<SUP>14</SUP>C]-glucose oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP(10<SUP>-3</SUP>M) were used and the inhibitory effects of YH1238 and YH1885 on acid secretion were compared with known proton pump inhibitors such as omeprazole and SK&amp;F 96067. Dibutyryl cAMP stimulated the [<SUP>14</SUP>C]-aminopyrine accumulation and [<SUP>14</SUP>C]-glucose oxidation, which were inhibited by YH1238, YH1885, SK&amp;F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on [<SUP>14</SUP>C]-aminopyrine accumulation in stimulated gastric cells were more potent than that of SK&amp;F 96067 at the concentration of 10<SUP>-5</SUP>M. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents.