Neural Adaptation of Beta Adrenergic Receptor Subtypes after Chronic Imipramine Treatment A Quantitative Autoradiographic Study
Neural Adaptation of Beta Adrenergic Receptor Subtypes after Chronic Imipramine Treatment A Quantitative Autoradiographic Study
- Hae-Young Park Young-Sook Hong Chan-Woong Park
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제1권 제2호
- 등재여부 : KCI등재
- 1997.01
- 161 - 167 (7 pages)
<P> This study compares the subtypes of central beta adrenergic receptors (ARs) of brains of untreated rats with those of imipramine-treated rats. Beta adrenergic receptors were measured by quantitative autoradiography of the binding of <SUP>3</SUP>H-dihydroalprenolol (<SUP>3</SUP>H-DHA) in coronal sections of rat brain. Repeated treatment of rats with imipramine significantly reduced the binding of <SUP>3</SUP>H-DHA to beta-1 AR in many brain areas, especially throughout the cerebral cortex, hippocampus, thalamus, and amygdala. Significant reductions of the binding of <SUP>3</SUP>H-DHA to beta-2 AR were not found in any area of the brain. These data suggests that a selective down-regulation of beta-1 AR may be involved in the adaptive changes occurring after prolonged imipramine treatment.