Renal Handling of Sodium and Potassium in Cadmium Exposed Rats
Renal Handling of Sodium and Potassium in Cadmium Exposed Rats
- Yung Kyu Kim Yang Saeng Park
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제2권 제4호
- 등재여부 : KCI등재
- 1998.01
- 503 - 510 (8 pages)
<P> Effects of cadmium exposure on renal Na<SUP>⁢</SUP> and K<SUP>⁢</SUP> transports were studied in rats. During the course of cadmium treatment (2 mg Cd/kg/day, s.c. injections for 3 weeks) renal tubular transports of Na<SUP>⁢</SUP> and K<SUP>⁢</SUP> were evaluated by lithium clearance technique. During the early phase (first week) of cadmium treatment, urinary Na<SUP>⁢</SUP> excretion decreased drastically and this was due to an increased Na<SUP>⁢</SUP> reabsorption both in the proximal and distal nephrons. During the late phase (third week) of cadmium treatment, filtered Na<SUP>⁢</SUP> load was decreased by reduction in GFR, but the renal Na<SUP>⁢</SUP> excretion returned to the control level due to impaired Na<SUP>⁢</SUP> transport in the proximal tubule. Urinary excretion of K<SUP>⁢</SUP> did not change during the early phase, but it rose markedly during the late phase of cadmium treatment. These results indicate that a light cadmium intoxication induces a Na<SUP>⁢</SUP> retention, and a heavy intoxication results in a K<SUP>⁢</SUP> loss. Possible mechanisms for these changes are discussed.