상세검색
최근 검색어 전체 삭제
다국어입력
즐겨찾기0
커버이미지 없음
KCI등재 학술저널

Renal Handling of Sodium and Potassium in Cadmium Exposed Rats

Renal Handling of Sodium and Potassium in Cadmium Exposed Rats

  • 4

<P> Effects of cadmium exposure on renal Na<SUP>&#8290;</SUP> and K<SUP>&#8290;</SUP> transports were studied in rats. During the course of cadmium treatment (2 mg Cd/kg/day, s.c. injections for 3 weeks) renal tubular transports of Na<SUP>&#8290;</SUP> and K<SUP>&#8290;</SUP> were evaluated by lithium clearance technique. During the early phase (first week) of cadmium treatment, urinary Na<SUP>&#8290;</SUP> excretion decreased drastically and this was due to an increased Na<SUP>&#8290;</SUP> reabsorption both in the proximal and distal nephrons. During the late phase (third week) of cadmium treatment, filtered Na<SUP>&#8290;</SUP> load was decreased by reduction in GFR, but the renal Na<SUP>&#8290;</SUP> excretion returned to the control level due to impaired Na<SUP>&#8290;</SUP> transport in the proximal tubule. Urinary excretion of K<SUP>&#8290;</SUP> did not change during the early phase, but it rose markedly during the late phase of cadmium treatment. These results indicate that a light cadmium intoxication induces a Na<SUP>&#8290;</SUP> retention, and a heavy intoxication results in a K<SUP>&#8290;</SUP> loss. Possible mechanisms for these changes are discussed.

로딩중