Electroencephalographic Effects of Chlorpromazine in Rats

Electroencephalographic Effects of Chlorpromazine in Rats

<P> <I> </I>The effects of an antipsychotic, chlorpromazine, on the electroencephalogram (EEG) were observed while rats were awake but immobile. The time course and the dose-dependency of the EEG changes were examined. The method of the power spectrum analysis was used to examine the EEG changes by the drug. The bands were divided into delta (1∼3.5 Hz), theta (3.5∼8 Hz), alpha (8∼13 Hz), beta1 (13∼21 Hz), beta2 (21∼30 Hz) and gamma (30∼50 Hz). In rats, the low dose of chlropromazine (1 mg/kg, i.p.) produced a significant increase in the power of the beta1 band. The higher doses (5, 10 mg/kg, i.p.) produced a significant increase in the power of the delta, theta, alpha and beta1 bands, and the decrease in the power of the gamma band. The powers of the bands changed dose-dependently. Then, the authors discussed whether the EEG effects produced by a drug are associated with the accompanying behavioral changes specifically.