Effect of Kainic Acid on the Phosphorylation of Mitogen Activated Protein Kinases in Rat Hippocampus
Effect of Kainic Acid on the Phosphorylation of Mitogen Activated Protein Kinases in Rat Hippocampus
- Je-Seong Won Jin-Koo Lee Seong-Soo Choi Dong-Keun Song Sung-Oh Huh Yung-Hi Kim Hong-Won Suh
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제5권 제6호
- 등재여부 : KCI등재
- 2001.01
- 451 - 456 (6 pages)
<P> In rat hippocampus, kainic acid (KA; 10 mg/kg; i.p.) increased the phosphorylated forms of ERK1/2 (p-ERK1/2) and Jun kinase1 (p-JNK1), but not p-JNK2 and p38 (p-p38). The preadministration with cycloheximide (CHX; 5 mg/kg; i.p.) inhibited KA-induced increase of p-JNK1, but not p-ERK1/2. Surprisingly, the phosphorylated upstream MAP kinase kinases (p-MKKs) were not correlated with their downstream MAP kinases. The basal p-MKK1/2 levels were completely abolished by KA, which were reversed by CHX. In addition, p-MKK4 and p-MKK3/6 levels were enhanced by CHX alone, but were attenuated by KA. Thus, our results showed that KA increased the p-ERK and p-JNK levels in rat hippocampus, which were not parallel with their classical upstreamal kinases.