Regulation of [<SUP>3</SUP>H]Norepinephrine Release by Opioids in Human Cerebral Cortex
Regulation of [<SUP>3</SUP>H]Norepinephrine Release by Opioids in Human Cerebral Cortex
- Ran-Sook Woo Byoung-Soo Shin Chul-Jin Kim Min-Soo Shin Min-Suk Jeong Rong-Jie Zhao Kee-Won Kim
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제7권 제1호
- 등재여부 : KCI등재
- 2003.01
- 1 - 3 (3 pages)
To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for μ-, δ-, and κ-receptors on the high potassium (15 mM)-evoked release of [<SUP>3</SUP>H]NE. [<SUP>3</SUP>H]NE release induced by high potassium was calcium-dependent and tetrodotoxin-sensitive. [D-Pen<SUP>2</SUP>, D-Pen<SUP>5</SUP>]enkephalin (DPDPE) and deltorphin II (Delt II) inhibited the stimulated release of norepinephrine in a dose-dependent manner. However, Tyr-D-Ala-Gly-(Me)Phe-Gly-ol and U69,593 did not influence the NE release. Inhibitory effect of DPDPE and Delt-II was antagonized by naloxone, naltrindole, 7-benzylidenaltrexone and naltriben. These results suggest that both δ<SUB>1</SUB> and δ<SUB>2</SUB> receptors are involved in regulation of NE release in human cerebral cortex.