Effects of Nitric Oxide on Inhibitory Receptors of Rod Bipolar Cells of Rat Retina
Effects of Nitric Oxide on Inhibitory Receptors of Rod Bipolar Cells of Rat Retina
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제9권 제6호
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2005.01347 - 352 (6 pages)
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The effects of nitric oxide (NO) on inhibitory neurotransmitter receptors and some types of inhibitory receptors in dissociated rod bipolar cell (RBC) were investigated. In the whole cell voltage-clamping mode, the gamma-aminobutyric acid (GABA) activated current showed both sustained and transient components. GABA activated transient current was fully blocked by bicuculine, a GABA<SUB>A</SUB> receptor antagonist. The cis-4-aminocrotonic acid (CACA), a GABA<SUB>C</SUB> receptor agonist, evoked the sustained current that was not blocked by bicuculline (BIC). Glycine activated the transient current. These results indicate that the RBCs possess GABA<SUB>A</SUB>, GABA<SUB>C</SUB>, and glycine inhibitory receptors. Sodium nitroprusside (SNP), a NO analogue, reduced the currents activated by GABA<SUB>A</SUB> receptor only, however, did not reduce the currents activated by either GABA<SUB>C</SUB> or glycine receptors. This study signifies further that only NO depresses the fast inhibitory response activated by GABA<SUB>A</SUB> receptor in RBC. We, therefore, postulate that NO might depress the light-on/off transient inhibitory responses in RBCs in the rat retina.
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