Effects of Nitric Oxide on Inhibitory Receptors of Rod Bipolar Cells of Rat Retina
Effects of Nitric Oxide on Inhibitory Receptors of Rod Bipolar Cells of Rat Retina
- No-Gi Park Sun-Ho Bai Chang-Sub Jung Myung-Hoon Chun
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제9권 제6호
- 등재여부 : KCI등재
- 2005.01
- 347 - 352 (6 pages)
The effects of nitric oxide (NO) on inhibitory neurotransmitter receptors and some types of inhibitory receptors in dissociated rod bipolar cell (RBC) were investigated. In the whole cell voltage-clamping mode, the gamma-aminobutyric acid (GABA) activated current showed both sustained and transient components. GABA activated transient current was fully blocked by bicuculine, a GABA<SUB>A</SUB> receptor antagonist. The cis-4-aminocrotonic acid (CACA), a GABA<SUB>C</SUB> receptor agonist, evoked the sustained current that was not blocked by bicuculline (BIC). Glycine activated the transient current. These results indicate that the RBCs possess GABA<SUB>A</SUB>, GABA<SUB>C</SUB>, and glycine inhibitory receptors. Sodium nitroprusside (SNP), a NO analogue, reduced the currents activated by GABA<SUB>A</SUB> receptor only, however, did not reduce the currents activated by either GABA<SUB>C</SUB> or glycine receptors. This study signifies further that only NO depresses the fast inhibitory response activated by GABA<SUB>A</SUB> receptor in RBC. We, therefore, postulate that NO might depress the light-on/off transient inhibitory responses in RBCs in the rat retina.