The Inhibitory Effect of Quercetin-3-O-Ղ-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats
The Inhibitory Effect of Quercetin-3-O-Ղ-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats
- Young Sil Min Se Eun Lee Seung Tae Hong Hyun Sik Kim Byung-Chul Choi Sang Soo Sim Wan Kyun Whang Uy
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제13권 제4호
- 등재여부 : KCI등재
- 2009.01
- 295 - 300 (6 pages)
It was evaluated the inhibitory action of quercetin-3-O-Ղ-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.