Antioxidant Effect of CoQ<SUB>10</SUB> on N-nitrosodiethylamine-induced Oxida</SUB>tive Stress in Mice
Antioxidant Effect of CoQ<SUB>10</SUB> on N-nitrosodiethylamine-induced Oxida</SUB>tive Stress in Mice
- Ho Sun Song Hee Rae Kim Tae Wook Park Bong Jae Cho Mi Young Choi Chang Jong Kim Uy Dong Sohn Sang So
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제13권 제4호
- 등재여부 : KCI등재
- 2009.01
- 321 - 326 (6 pages)
The antioxidant effect of CoQ<sub>10</sub> on N-nitrosodiethylamine (NDEA)-induced oxidative stress was investigated in mice. Food intake and body weight were similar in both CoQ<sub>10</sub> and control groups during the 3-week experimental period. NDEA significantly increased the activities of typical marker enzymes of liver function (AST, ALT and ALP) both in control and CoQ<sub>10</sub> groups. However, the increase of plasma aminotransferase activity was significantly reduced in the CoQ<sub>10</sub> group. Lipid peroxidation in various tissues, such as heart, lung, liver, kidney, spleen and plasma, was significantly increased by NDEA, but this increase was significantly reduced by 100 mg/kg of CoQ<sub>10</sub>. Superoxide dismutase activity increased significantly upon NDEA-induced oxidative stress in both the control and CoQ<sub>10</sub> groups with the effect being less in the CoQ<sub>10</sub> group. Catalase activity decreased significantly in both the control and CoQ<sub>10</sub> groups treated with NDEA, again with the effect being less in the CoQ<sub>10</sub> group. The lesser effect on superoxide dismutase and catalase in the NDEA-treated CoQ<sub>10</sub> group is indicative of the protective effect CoQ<sub>10</sub>. Thus, CoQ<sub>10</sub> can offer useful protection against NDEA-induced oxidative stress.