Antinociception Effect and Mechanisms of Campanula Punctata Extract in the Mouse
Antinociception Effect and Mechanisms of Campanula Punctata Extract in the Mouse
- Soo-Hyun Park Yun-Beom Sim Soon-Sung Lim Jin-Kyu Kim Jin-Koo Lee Hong-Won Suh
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제14권 제5호
- 등재여부 : KCI등재
- 2010.01
- 285 - 289 (5 pages)
In the present study, the antinociceptive profiles of Campanula punctata extract were examined in ICR mice. The Campanula punctata contain a large dose of saponin. Campanula punctata extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Campanula punctata extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7Ռg) was diminished by Campanula punctata extract. Intraperitoneal (i.p.) pretreatment with yohimbine (Ձ<sub>2</sub>-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Campanula punctata extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Campanula punctata extract in the writhing test. Our results suggest that Campanula punctata extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Campanula punctata extract may be mediated by Ձ<sub>2</sub>-adrenergic receptor, but not opioidergic and serotonergic receptors.