Inhibitory Effects of <I>Corni Fructus</I> Extract on Angiogenesis and Adipogenesis

Inhibitory Effects of <I>Corni Fructus</I> Extract on Angiogenesis and Adipogenesis

Natural products in Chonnam, Korea were screened via anti-angiogenesis experiments, and 1 candidate product was identified, <i>Corni fructus</i>, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. <i>C. fructus</i> extract (CFE) exhibits an angiogenesis inhibi&lt;/I&gt;tory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and adipogenesis-related signal molecules in the western blotting was reduced by increasing the amount of added CFE. Moreover, a diet supplemented with CFE was deemed more effective in inducing weight loss in LB mice than a representative synthetic diet drug, orlistat, which incidently caused the side effect of denuding the mice of their hair. These results indicate that <i>C. fructus</i> may prove to be a useful anti-adipogenic compound, and these <i>in vitro</i> results may be reflected later under <i>in vivo </i>conditions.