Inhibitory Effects of <I>Corni Fructus</I> Extract on Angiogenesis and Adipogenesis
Inhibitory Effects of <I>Corni Fructus</I> Extract on Angiogenesis and Adipogenesis
- Jae-Ho Hwang Jong-Deog Kim
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제15권 제1호
- 등재여부 : KCI등재
- 2011.01
- 43 - 52 (10 pages)
Natural products in Chonnam, Korea were screened via anti-angiogenesis experiments, and 1 candidate product was identified, <i>Corni fructus</i>, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. <i>C. fructus</i> extract (CFE) exhibits an angiogenesis inhibi</I>tory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and adipogenesis-related signal molecules in the western blotting was reduced by increasing the amount of added CFE. Moreover, a diet supplemented with CFE was deemed more effective in inducing weight loss in LB mice than a representative synthetic diet drug, orlistat, which incidently caused the side effect of denuding the mice of their hair. These results indicate that <i>C. fructus</i> may prove to be a useful anti-adipogenic compound, and these <i>in vitro</i> results may be reflected later under <i>in vivo </i>conditions.