Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
- Soung Baek Jang Dongju Kim Seong Yeon Kim Changhee Park Ji Hoon Jeong Hyo-Jeong Kuh Jaehwi Lee
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제17권 제1호
- 등재여부 : KCI등재
- 2013.01
- 9 - 13 (5 pages)
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.