The Pathophysiologic Roles of TRPM7 Channel
The Pathophysiologic Roles of TRPM7 Channel
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제18권 제1호
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2014.0115 - 23 (9 pages)
- 3
Transient receptor potential melastatin 7 (TRPM7) is a member of the melastatin-related subfamily and contains a channel and a kinase domain. TRPM7 is known to be associated with cell proliferation, survival, and development. It is ubiquitously expressed, highly permeable to Mg<sup>2＋</sup> and Ca<sup>2＋</sup>, and its channel activity is negatively regulated by free Mg<sup>2＋</sup> and Mg-complexed nucleotides. Recent studies have investigated the relationships between TRPM7 and a number of diseases. TRPM7 regulates cell proliferation in several cancers, and is associated with ischemic cell death and vascular smooth muscle cell (VSMC) function. This review discusses the physiologic and pathophysiologic functions and significance of TRPM7 in several diseases.
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