Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization
Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization
- Joo Min Park Sung-Cherl Jung Su-Yong Eun
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제18권 제6호
- 등재여부 : KCI등재
- 2014.01
- 457 - 460 (4 pages)
At central synapses, activity-dependent synaptic plasticity has a crucial role in information pro-cessing, storage, learning, and memory under both physiological and pathological conditions. One widely accepted model of learning mechanism and information processing in the brain is Hebbian Plasticity: long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD are respectively activity-dependent enhancement and reduction in the efficacy of the synapses, which are rapid and synapse-specific processes. A number of recent studies have a strong focal point on the critical importance of another distinct form of synaptic plasticity, non-Hebbian plasticity. Non-Hebbian plasticity dynamically adjusts synaptic strength to maintain stability. This process may be very slow and occur cell-widely. By putting them all together, this mini review defines an important conceptual difference between Hebbian and non-Hebbian plasticity.